In the context of the 2025 RSA Regional Futures Conference (https://www.regionalstudies.org/events/2025-regional-futures/), ISABEL organizes a co-creation workshop, sponsored by RSA, at The Cumberland Hotel in London on Friday, 14 November 2025, from 11:00 to 15:00. The workshop’s main aim is to present insights on the conceptualization of job creation and destruction in the context of the twin transition and on opportunities for harnessing AI and social sciences for evidence-based regional labour market analyses and policies. A group of researchers and experts working on labour markets, AI, regional development, and the green and digital transitions, will discuss regional labor market transformations in the context of the potential synergies between social sciences and AI to study these transformations, seeking co-creation of knowledge and feedback exchange.